Located at the Smilow Center for Translational Research Auditorium/Commons at Penn Medicine (enter through Perelman Center for Advanced Medicine).
7:30-8:00 AM
Registration
8:00-8:15 AM
Welcome
MORNING SESSION
8:15-8:40 AM
Professor Rob Bristow, MD, PhD, FRCPC, FMedSci
Molecular Indices and New Models for Aggressive Hereditary Prostate Cancer
8:40-9:05 AM
Irfan Asangani, PhD
Inducing BRCAness in HR Proficient Metastatic Prostate Cancer
9:05-9:30 AM
Salma Kaochar, PhD
Genetic and Epigenetic Mechanisms of Aggressive Prostate Cancer
9:30-9:55 AM
Kara Maxwell, MD, PhD
Genetics of Prostate Cancer Risk
9:55-10:15 AM
BREAK
10:15-10:40 AM
Bryson Katona, MD, PhD, AGAF, CGAF
Update on GI Cancer Risk and Screening in BRCA1/2 Carrier
10:40-11:05 AM
Victor Velculescu, MD, PhD
Early Detection of Ovarian Cancer Using Cell-Free DNA Fragmentomes and Protein Biomarkers
11:05-11:30 AM
Trevor Pugh, PhD, FACMG
Cell-Free DNA Sequencing for Early Detection of Hereditary Cancer
11:30-11:55 AM
Powel Brown, MD, PhD
PARP Inhibitors for Breast Cancer Prevention
11:55-1:00 PM
LUNCH
AFTERNOON SESSION
1:00-1:25 PM
Maggie Mullen, MD
Replication Stress Marker Phospho-RPA2 Predicts Response to DNA Damaging Agents in Homologous Recombination-Proficient Ovarian Cancer
1:25-1:50 PM
Titia de Lange, PhD
Attenuation of ATM Signaling by ROS Delays Replicative Senescence at Physiological Oxygen
1:50-2:15 PM
Maria Jasin, PhD
Protecting the Genome by Homologous Recombination
2:15-2:45 PM
BREAK
2:45-4:00 PM
Patrick Sung, DPhil
Global Prize Presentation and Keynote
Mechanism of BRCA1/BRCA2-dependent DNA Damage Repair
4:00-4:15 PM
Wrap Up and Evaluations
End of accredited portion
4:30-6:00 PM
Breakthroughs & Discoveries Panel
Moderated by Susan Domchek, MD
Featuring Patrick Sung, DPhil, Kara Maxwell, MD, PhD, and Gareth Evans, MD, PhD, FRCP, FRCOG
This lay session is open to the public.