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Genetic testing

Ambiguous Genetic Test Results Can Be Unsettling. Worse, They Can Lead to Needless Surgeries

Washington Post

Basser Executive Director Susan Domchek, MD, was quoted in a story on the ambiguity of certain genetic tests and how “variants of unknown significance” (VUS) can guide cancer treatments, despite a lack of evidence to support those decisions.

Mutations Commonly Linked to Breast Cancer Found to Pose No Increased Risk, Population Study Reveals

Penn Medicine News

Several genetic mutations previously linked to breast cancer and included on commercial genetic tests were found not to increase a woman’s risk of disease, according to a population study published today in the New England Journal of Medicine, involving the Basser Center and Penn Medicine.

ALC1 Links Chromatin Accessibility to PARP Inhibitor Response in Homologous Recombination-Deficient Cells

Nature Cell Biology

Researchers led by Basser Director of Basic Science Roger Greenberg, MD, PhD, found that eliminating an enzyme called ALC1 can potentially increasing the effectiveness of PARP inhibitors in cancer treatment.

Cancer survivor

10 Cancer Super Survivors You Need to Follow on Instagram Right Now

Parade

This helpful list of cancer survivors to follow on Instagram includes Alejandra Campoverdi, our partner on LATINX & BRCA.

Erika Stallings

Everviolet Chats: Erika Stallings

Everviolet

Everviolet talked to Basser Young Leadership Council co-chair Erika Stallings about her experience with BRCA and hereditary cancer.

Real-world integration of genomic data into the electronic health record: the PennChart Genomics Initiative

Nature

Penn Medicine scientists including Basser Executive Director Susan Domchek, MD, and Basser Director of Genetics Katherine Nathanson, MD, recently published a paper on the PennChart Genomics Initiative.

Penn’s Basser Center for BRCA Awards 2020 Basser Global Prize to Bella Kaufman from Israel’s Sheba Medical Center

Penn Medicine News

We’re honored to award the 2020 Basser Global Prize to Bella Kaufman, MD, of Sheba Medical Center at Tel Hashomer in Israel. Dr. Kaufman has had a crucial role in the development of PARP inhibitors for the treatment of BRCA-related cancers. 

Diagnostic Radiation Below the Waist May Increase Risk for Testicular Cancer

Healio

Early and repeated exposures to diagnostic imaging, such as X-rays and CT scans, may increase the risk of testicular cancer, according to a new study published in PLOS ONE and led by Katherine L. Nathanson, MD, Basser Director of Genetics.

Trebek

Spotting These Pancreatic Cancer Symptoms Could Save Your Life

Yahoo Lifestyle

Basser clinician Kim Reiss-Binder, MD, was quoted in an article on symptoms that often occur in the later stages of pancreatic cancer.

Global Connections: COVID & CANCER

Global Connections

Former NPR host Robert Siegel interviewed world cancer experts Dr. Susan Domchek, the Basser Center's Executive Director, and Dr. Mary-Claire King.

Nathanson

Penn Medicine Researchers Receive $5.4 million Grant to Find Genetic Drivers of Testicular Cancer

Penn Medicine News

A team of researchers led by Katherine L. Nathanson, MD, Basser Director of Genetics, Deputy Director of the Abramson Cancer Center, and the Pearl Basser Professor for BRCA-Related Research, was recently awarded $5.4 million over five years from the National Institutes of Health to continue the long-standing genomics work of the TEsticular CAncer Consortium (TECAC).

Pod is a Woman: Breast Cancer Awareness

Pod is a Woman

For Breast Cancer Awareness Month, Basser Center Executive Director Susan Domchek appeared as a guest on Pod is a Woman, Alejandra Campoverdi's podcast.

Breast cancer graphic

Mutation Rates in Cancer Susceptibility Genes in Patients With Breast Cancer With Multiple Primary Cancers

JCO Precision Oncology

The Basser Center's Kara Maxwell, MD, PhD, led a study exploring the risk of developing a second primary cancer in BRCA1/2 mutation carriers.

Olaparib and Durvalumab in Patients with Germline BRCA-Mutated Metastatic Breast Cancer

The Lancet

The Lancet published an article on the MEDIOLA trial, a study led by Basser Executive Director Susan Domchek, MD, which explored the use of PARP inhibitors and immunotherapy as treatment options for BRCA-related breast cancer.

TP53

Study Finds New Mutation in Ashkenazi Jews

Jewish Exponent

Basser researcher Kara N. Maxwell, MD, PhD, is the lead author of a recent study about a newly-described genetic mutation in the TP53 gene, which can increase the risk of developing multiple types of cancer. Basser genetic counselor Jacquelyn Powers, MS, LCGC, was a co-first author on the study.

TP53

Study Finds New Mutation in Ashkenazi Jews

Jewish Exponent

Basser researcher Kara N. Maxwell, MD, PhD, is the lead author of a recent study about a newly-described genetic mutation in the TP53 gene, which can increase the risk of developing multiple types of cancer. Basser genetic counselor Jacquelyn Powers, MS, LCGC, was a co-first author on the study.

Genetic Counseling for Cancer Shifts to a New Era of Virtual Care

Cure Magazine

The latest episode of the “CURE Talks Cancer” podcast features Basser genetic counselor Dana Farengo Clark discussing how genetic counseling is adjusting to the new normal and shifting into the virtual era of cancer care.

Angela Bradbury

Angela R. Bradbury, MD, on Telemedicine in Genetic Counseling

Cancer Network

Cancer Network interviewed the Basser Center's Angela R. Bradbury, MD, about Penn’s efforts to continue genetic counseling during the COVID-19 pandemic.