To locate a genetic counselor at Penn Medicine, contact the MacDonald Cancer Risk Evaluation Center at 215-349-9093. You can also search the National Society of Genetic Counselors’ Find a Genetic Counselor tool or contact your local cancer center. Genetic counselors who perform BRCA testing are often a part of the breast group of academic medical centers or cancer centers.
Genetic Testing in Primary Care Practice: Where We Are and Where We Are Headed
In this informative webinar for primary care providers, Susan Domchek, MD, reviews the nuances, controversies, and potential advantages and detriments of genetic testing for breast cancer susceptibility. Executive Director of the Basser Center and contributor to more than 200 articles on the genetics of breast cancer, Dr. Domchek offers an update on genetic testing strategies for breast and ovarian cancer risk; describes the testing and disclosure procedures at the Basser Center; considers the importance of Ashkenazi Jewish ancestry in cancer genetics; and discusses issues related to decreasing the barriers to population screening for BRCA1/2 mutations.
BRCA Testing Laboratory Resources
This information is tailored toward breast and ovarian cancer susceptibility genetic testing and is not intended to reflect all labs that offer genetic testing; information is subject to change. Please refer to https://www.cancer.gov/types/breast/hp/breast-ovarian-genetics-pdq for an overview on the genetics of breast and gynecological cancers.
- Most commercial labs offer options of single gene testing (BRCA1/2 only) as well as multigene panel testing options.
- Patients with active hematologic malignancy or prior allogeneic stem cell transplant cannot use blood or saliva (buccal) samples for genetic testing. Testing for these patients requires DNA from fibroblast samples via skin punch and cell culture.
- Providers are responsible for ensuring informed consent from patients; informed consent documents are available on most lab websites. Labs may request patient and/or provider signature (or e-signature) to indicate informed consent has been obtained.
Insurance-Specific Requirements & Reporting
Medicare, Aetna, Cigna, UHC: These insurances each have specific BRCA testing criteria for insurance coverage.
- Cigna has a specific precertification requirement for individuals to receive pre-testing genetic counseling from a genetics provider meeting Cigna standards.
- United Health Care (UHC): Some UHC insurances require provider to submit pre-authorization via UHC portal
Laboratories* offering hereditary breast and ovarian cancer genetic testing and not limit to breast and ovarian
*This is not a comprehensive list of all laboratories.
Ambry - https://www.ambrygen.com
Color Genomics - https://www.color.com
GeneDX - https://www.genedx.com
Invitae - https://www.invitae.com
LabCorp - https://www.labcorp.com/
Myriad - https://myriadmyrisk.com/
Quest Diagnostics - https://www.questdiagnostics.com/