2025 Scientific Symposium Poster Session

Poster 1 

Integration of Germline Genetic Testing into Routine Clinical Practice in Urology 
 

Michael Wang, Caitlin Orr, PhD, Jacquelyn Powers, MS, CGC, Kelsey Spielman, MS, CGC, Carleigh Keegan, CGC, Heather Symecko, MPH, Susan M. Domchek, MD, Daniel J. Lee, MS, MD, Kara N. Maxwell, MD, PhD 

University of Pennsylvania

Poster 2 

PLATPARP: A Phase II Single-Arm Trial of Maintenance Niraparib in Platinum-Sensitive Metastatic Castration-Resistant Prostate Cancer (mCRPC) with DNA Repair Defects
 

Vivek Narayan, Yi Lian; Alexandra Torres; Caitlin Orr; Michael Wang; Joann Miller; Jennifer Louie; Daniel Lee; Naomi Haas; Samuel U. Takvorian; E. Paul Wileyto; Susan Domchek; Kara Maxwell

University of Pennsylvania

Poster 3 

Initial Biopsy Results of the PATROL Study: Prostate Screening for People with Inherited Risk of Developing Aggressive Prostate Cancer
 

Daniel Lee¹, Caitlin Orr^1,2, Kara N. Maxwell^1,2, Andrew A. Amini³, Christopher Amling⁵, Aileen J. Feng³, Stephanie Goettl⁵, Kristin Follmer⁶, Grace Jun⁶, Chenee Holcomb⁶, Shelley R. McCormick⁴, Margaret R. O'Dea³, Maxwell Poole⁵, Linda H. Rodgers⁴, Alexandra Sokolova⁵, Maliha Tayeb^1,2, Erika Wolff ⁶, Keyan Salari^3,4, Heather H. Cheng^6,7 Daniel W. Lin^6,7   
 

¹ University of Pennsylvania, Philadelphia, PA

² Abramson Cancer Center, Philadelphia, PA

³ Massachusetts General Hospital, Harvard Medical School, Boston, MA

⁴ Center for Cancer Risk Assessment, Massachusetts General Hospital Cancer Center, Boston, MA 

⁵ OHSU Knight Cancer Institute, Portland, OR

⁶ University of Washington, Seattle, WA

⁷ Fred Hutchinson Cancer Center, Seattle, WA

Poster 4 

Investigating Mechanisms Driving Aggressive BRCA2 Related Prostate Cancer
 

Taylor Crawford, Nabamita Boruah

Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Poster 5 

Repression of PRMT Activities Sensitize Homologous Recombination-Proficient Ovarian and Breast Cancer Cells to PARP Inhibitor Treatment
 

Youyou Zhang^1,2*‡, Mu Xu^1*, Jiao Yuan¹, Zhongyi Hu¹, Junjie Jiang¹, Yanrong Sun¹, Jie Huang¹, Yuxin Wang¹, Bingwei Wang¹, Jianfeng Shen¹, Meixiao Long³, Yi Fan^4,5, Kathleen T. Montone⁶, Janos L. Tanyi^2,4,7, Sarah H. Kim^2,4, Omid Tavana⁸, Robert H. Vonderheide⁴, Ho Man Chan⁸, Susan M. Domchek^4,9,10, Xiaowen Hu^1,2†, Lin Zhang^1,2,4†   
 

¹ Center for Women's Health and Reproductive Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA 

² Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA 

³ Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus, Ohio, 43210, USA 

⁴ Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA 

⁵ Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA 

⁶ Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA 

⁷ Center for Gynecologic Cancer Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA 

⁸ Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Waltham, Massachusetts, 02451, USA 

⁹ Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA 

¹⁰ Basser Center for BRCA, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA 

^* These authors contributed equally  ^‡ Current address: GlaxoSmithKline, Collegeville, PA 19426, USA   

^† Corresponding authors 

Poster 6

CRISPR/Cas9 Screens and Executable Modelling of DNA Damage Response Reveal Genetic Vulnerabilities in BRCA1-Deficient Cells with Acquired PARP Inhibitor Resistance
 

Rimma Belotserkovskaya¹, Matthew Clarke², Jasmine Fisher² and Steve Jackson<sup>1 

1</sup> CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Building, Robinson Way   Cambridge, UK CB2 0RE   

² UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK

Poster 7

Mechanisms of Therapy Resistance to PARP Inhibitors in Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma
 

Austin Good, William Vostrejs, Sean O'Connor, Srishti Rathore, Timour Baslan, Kim Reiss Binder, and Ben Stanger   

Department of Pathology and Laboratory Medicine,  Hospital of the University of Pennsylvania, Philadelphia, PA  Department of Medicine, Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA  Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA

Poster 8 

Assessing the Therapeutic Potential of PARPi and PROTACs in BRCA-Mutated Cancers
 

Sehbanul Islam¹, Jitendra Gaur², Manish Kumar Mehra², Thomas Beer², Hsin-Yao Tang², Joel Cassel³, Joe Salvino² and Luca Busino¹ 
 

¹ University of Pennsylvania, Perelman School of Medicine, Department of Cancer Biology, Philadelphia, 19104, PA 

² Medicinal Chemistry and Molecular and Cellular Oncogenesis (MCO) Program, The Wistar Institute, Philadelphia, 19104, PA ³ Molecular Screening and Protein Expression Shared Resource, The Wistar Institute, Philadelphia, 19104, PA  

Poster 9

Current Therapeutic Trials at Basser Center for BRCA
 

Alexandra Torres, Megan Aaron, Susan Domchek, Kim Reiss, Payal Shah

University of Pennsylvania

Poster 10

Platform to Study DNA Damage Response Inhibitor (DDRi) Resistance and Identify Biomarkers of Response to New Therapies for BRCA1/2 Mutant Ovarian Cancers
 

Ian Heller¹, Matthew Anderson¹, Amaryllis Ortiz¹, Sergey Medvedev¹, Xiaoyin Shan¹, Haineng Xu¹, Xiaolei Wang¹, Eric Brown², Hyoung Kim¹, Fiona Simpkins<sup>1       

1</sup> Dept. of OB-GYN, University of Pennsylvania 
² Dept. of Cancer Biology, University of Pennsylvania

Poster 11

Prevalence of Helicobacter Pylori and Risk Factors Among BRCA1 and BRCA2 Carriers
 

Kole H. Buckley¹, Linda Zhu¹, Kevin Dinh¹, Ryan Hausler², Ariana D. Majer¹, Keely A. Beyries¹, Kara N. Maxwell², Bryson W. Katona<sup>1   

1</sup> Division of Gastroenterology and Hepatology 
² Division of Hematology and Oncology  University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States    

Poster 12

Single-Cell Clonal Dynamics in Gastric Tissues of BRCA1/2 Carriers
 

Madison Wahlsten¹, Kole H. Buckley², Michaela E. Dungan², Julia E. Youngman², Bryson W. Katona², Sydney M. Shaffer<sup>1,3 

1</sup> Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA 

² Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 
³ Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA  

Poster 13

Sympathetic Innervation Inhibits High Grade Serous Ovarian Cancer Intestinal Metastasis in the Setting of BRCA1/2 Dysfunction
 

Matthew Knarr^1,2, Katherine Cummins^1,2, Hunter Reavis^1,2, Timothy Lippert^2,3, Ryan Hausler², Jamie Moon⁴, Paola Vermeer⁵, David Hoon⁴, Roger Greenberg^1,2, Ronny Drapkin<sup>1,2    

1</sup> Department of Obstetrics and Gynecology, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104 

² Penn Ovarian Cancer Research Center, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104 

³ Department of Cancer Biology, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104 

⁴ Department of Translational Molecular Medicine, Saint John's Cancer Institute, Providence Health Services, Santa Monica, CA, USA 
⁵ Cancer Biology & Immunotherapies Group, Sanford Research, 2301 East 60th St, Sioux Falls, SD 57104  

Poster 14

Unraveling The CDK9-BRCA1 Axis of DNA Damage Repair: A Breast Cancer Predisposition Pathway?
 

Cancer Epidemiology Program, H. Lee Moffitt Cancer Center & Research Institute , Tampa , FL , USA

Poster 15

Roles of RAD51C in Alkylation Damage Repair
 

Anna Palovcak-Lightbourn, Jehan Mody, Kara Bernstein 

University of Pennsylvania, Department of Biochemistry and Biophysics 

Poster 16

Comprehensive Analysis of Breast and Ovarian Cancer-Identified RAD51D Variants
 

Kristie E. Darrah ¹, Katherine Oppenheimer ², Nicole Banks¹, Ella Roberts², Gayatri Ganesan¹, Kara Bernstein<sup>1

1</sup> University of Pennsylvania
² University of Pittsburgh

Poster 17

Mammography Results in Male BRCA Carriers 
 

Authors:  Maliha Tayeb, BS, BA^1,2, Caitlin Orr, PhD^1,2, Roukiatou Sore, MPH⁸, Meredith Davies^1,7, David Lu, BA¹, Heather Symecko, MPH², Sarah Ehsan, MPH⁸, Heena Desai, MS^1,7, Ryan Hausler, MS^1,7, Bradley Wubbenhorst, MS, Abigail Doucette, MPH³, Peter E. Gabriel, MD^3,4, Katherine L. Nathanson, MD⁵, Christine E. Edmonds, MD⁶, Susan M. Domchek, MD^1,2,3, Anne Marie McCarthy, PhD^3,8, Kara N. Maxwell, MD, PhD<sup>1,2,3,7 

1</sup> Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

² Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 

³ Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 

⁴ Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 

⁵ Division of Translational Medicine & Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 

⁶ Hospital of the University of Pennsylvania, Department of Radiology 

⁷ Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 
⁸ Department of Biostatistics, Epidemiology and Informatics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

Poster 18

Clinicopathological Characteristics of Male Breast Cancer
 

Vishnu Maddipatla ¹, Maliha Tayeb ², Caitlin Orr ², Kara Maxwell ^2,3, Anupma Nayak ^3,4, Jennifer Q. Zhang <sup>1,3   

1</sup> Department of Surgery, University of Pennsylvania 

² Department of Medicine, University of Pennsylvania 

³ Abramson Cancer Center, University of Pennsylvania 

⁴ Department of Pathology, University of Pennsylvania  

Poster 19

Single Cell Sequencing of Male Breast Cancers Exhibit a Distinct Immunosuppressive Tumor Microenvironment
 

Nikhil Joshi¹, Jennifer Zhang<sup>2,3   

1</sup> Division of Oncology, Children's Hospital of Philadelphia 

² Abramson Cancer Center, University of Pennsylvania

³ Department of Surgery, University of Pennsylvania

Poster 20

Basser Center for BRCA: Current Studies and Initiatives
 

Basser Funded Investigators and Staff

Poster 21

HSP90 Buffers BRCA1 Mutations
 

Brant Gracia ¹, Patricia Montes ¹, Min Huang ², Junjie Chen ², Georgios Ioannis Karras <sup>1,3,4     

1</sup> Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA 

² Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 

³ Genetics and Epigenetics Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, Texas, USA 

⁴ Correspondence: gkarras@mdanderson.org

Poster 22

EMT Facilitates Tumorigenesis in BRCA1-deficient Mammary Epithelium
 

Neta Bar-Hai ^1,3, Rakefet Ben-Yishay¹, Sheli Arbili-Yarhi¹, Naama Herman², Vered Avidan-Noy², Tehillah Menes ^2,3, Daniel Rozin ^2,3, Aiham Mansour², Nora Balint-Lahat⁴, Gil Goldinger^3,4, Goni Hout-Siloni⁴ , Yaron E. Antebi⁵, Raanan Berger^1,3, Rinat Bernstein Molho^1,3 and Dana Ishay-Ronen<sup>1,3   

1</sup>Oncology institute, Shaba Medical Center, Tel Hashomer, Israel

²Department of General Surgery Shaba Medical Center, Tel Hashomer, Israel

³Affiliated with faculty of Medicine, Tel Aviv University, Tel Aviv, Israel 

⁴Institute of Pathology, Shaba Medical Center, Tel Hashomer, Israel

⁵Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

Poster 23

Suppression of Transcription-Associated Homologous Recombination by a G4 Helicase Restrains Cancer Genome Maintenance
 

Priyanka Basak^1*, Simran Khurana²*, Shalu Sharma²*, Sheetal Kooduvalli¹, Vijayalalitha Ramanaranayan¹, Xianzhen Zhou¹, Pedro J. Batista³, Travis Stracker^2#, Philipp Oberdoerffer<sup>1#   

1</sup> Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287 

² Radiation Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892 

³ Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, MD 20892 

* contributed equally  ^#Co-correspondence to travis.stracker@nih.gov and PO@jhmi.edu  

Poster 24

Patient Experiences with Genetic Test Result Release in the Setting of the 21st Century Cures Act Final Rule
 

Cameron Bell¹, Samantha Pipito², Ashika Mani³, Arravinth Anantharajah², Taylor Apostolico², Angela G. Arnold², Jacqueline Cappadocia², Dana Farengo Clark², Melissa Heller², Jessica M. Long², Derek Mann², Emma McKennon², Joanna Mercado², Jacquelyn Powers², Anna Raper⁴, Kelsey Spielman², Kara Maxwell², Mersedeh Rohanizadegan⁴, Payal Shah², Angela Bradbury², Susan M. Domchek², Rebecca Mueller¹, Jessica E. Ebrahimzadeh<sup>2   

1</sup> Master of Science in Genetic Counseling Program, Perelman School of Medicine, University of Pennsylvania 

² Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

³ Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 

⁴ Division of Medical Genetics, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA 

Poster 25

Preliminary Results from a Randomized Controlled Trial of Provider-Mediated Cascade Genetic Testing
 

Julia Gruberg, Victoria Groner, Catherine Fanjoy,  Giulia Ongaro, Dina Green, Magan Trottier, Fernanda C. G. Polubriaginof, Zsofia K. Stadler, Kenneth Offit,  Jada G. Hamilton

Memorial Sloan Kettering Cancer Center 

Poster 26

The eREACH Study: A Randomized Study of an eHEALTH Delivery Alternative for Cancer Genetic Testing for Hereditary Predisposition in Patients with Metastatic Cancers
 

Kimberley T. Lee¹, Brian Egleston²,  Sarah Brown¹,  Briana McLeod¹, Dominique Fetzer¹, Cara Cacioppo¹,  Janice Christiansen¹, Dana Clark¹, Susan Domchek¹, Jessica Ebrahimzadeh¹,   Linda Fleisher², Lauren Gutstein¹, Sarah Howe¹,  Kelsey Karpink¹, Enida Selmani¹, Lynne Wagner³, Michelle Weinberg¹, Kuang Yi-Wen⁴, Elisabeth Wood¹, The Penn Telegenetics Program¹, Angela R. Bradbury<sup>1   

1</sup> The University of Pennsylvania 

² Fox Chase Cancer Center 

³ University of North Carolina Lineberger Comprehensive Cancer Center   

⁴ Thomas Jefferson University Hospital  

Poster 27 

Barriers to Meeting Previvors' Supportive Care Needs: Genetic Counselors' Experiences  
 

Corinne Merlino, BS, Rebecca Mueller, PhD, LCGC, Dana Farengo-Clark, MS, LCGC 

The University of Pennsylvania, Masters of Science in Genetic Counseling Program, Division of Hematology and Oncology, Penn Medicine

Poster 28

A Randomized Study of Digital Versus Genetic Counselor Return of Actionable Genetic Research Results (The Penn Medicine Biobank Return of Results Program)
 

Anuja Rajendra Godbole¹, Sanjana Shastri¹, Elisabeth Wood¹, Sarah Brown¹, Lillian Phung¹, Brian Egleston², Demetrios Ofidis¹, Justin Feng¹, Rajia Mim¹, Sarah Howe¹, Lillian Hoffman-Andrews¹, Anjali Owens¹, Susan Domchek¹, Reed Pyeritz¹, Bryson Katona¹, Staci Kallish¹, Giorgio Sirugo¹, JoEllen Weaver¹, Katherine Nathanson¹, Dan Rader¹, Angela Bradbury<sup>1  

1</sup> University of Pennsylvania

² Fox Chase Cancer Center, Temple University 

Poster 29

Assessment of Reasons for Pancreatic Cancer Cessation or Deferral Amongst High Risk Individuals 

Grace G. Snyder¹, Daniel Clay², Sara Karley², Samantha Pipito³, Rebecca Mueller¹, Angela Bradbury³, Kara Maxwell³, Payal Shah³, Jessica M. Long³, Susan M. Domchek³, Bryson W. Katona<sup>2  

1</sup> Master of Science in Genetic Counseling Program, University of Pennsylvania Perelman School of Medicine 

² Division of Gastroenterology and Hepatology, University of Pennsylvania Perelman School of Medicine 

³ Division of Hematology and Oncology, University of Pennsylvania Health System  

Poster 30

Pancreatic Cancer Screening in High-Risk Individuals: Report from a Clinic-Based Registry
 

Brooke Levin, MS, CGC, Kristin Mattie, MS, CGC, Molly Sterner, MS, CGC, Hannah Weile, BS,  Christopher Deitch, MD, 

MD Anderson Cancer Center at Cooper  

Poster 31

Polygenic Risk Score for Breast Cancer Risk Prediction in BRCA1 and BRCA2 Carriers of Asian ancestry
 

Mei-Chee Tai¹, Joe Dennis², KOHBRA investigators, MYBRACA investigators, HRBCP investigators, SGBCC investigators, MaGic investigators, NCCS investigators, MyOvCa investigators, CIMBA consortium, Douglas Easton^2,3, Georgia Chenevix-Trench³, Antonis Antoniou², Soo-Hwang Teo^1,4, Weang-Kee Ho<sup>1,5 

1</sup> Cancer Research Malaysia 

² University of Cambridge 

³ Queensland Institute of Medical Research 

⁴ University of Malaya, 5University of Nottingham Malaysia  

Poster 32

The International BRCA1/2 Carrier Cohort Study (IBCCS): An Update on the Prospective Cohort and Ongoing Challenges
 

Yen Y. Tan^1,2, Renske Keeman³, Nadine Andrieu^4,5,6,7, Antonis C. Antoniou⁸, Douglas F. Easton^8,9, Christoph Engel¹⁰, Lenka Foretova¹¹, Anne-Marie Gerdes¹², Anna Jakubowska^13,14, Karin Kast¹⁵, Flora E. van Leeuwen², Catherine Nogues^16,17, Rita Schmutzler¹⁵, Christian F. Singer¹, Mads Thomassen^18,19,20, Marjanka K. Schmidt<sup>2,3   

1</sup> Department of Obstetrics & Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria ² Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands 

³ Division of Molecular Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

⁴ INSERM, U900, Paris, France 

⁵ Institut Curie, Paris, France

⁶ PSL Research University, Paris, France 

⁷ Mines ParisTech, Fontainebleau, France

⁸ Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK 

⁹ Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK

¹⁰ Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany 

¹¹ Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic 

¹² Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 

¹³ Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland 

¹⁴ Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland 

¹⁵ Center for Hereditary Breast and Ovarian Cancer, Center of Integrated Oncology, Medical Faculty, University Hospital Cologne, Cologne, Germany 

¹⁶ Département d'Anticipation et de Suivi des Cancers, Oncogénétique Clinique, Institut Paoli-Calmettes, Marseille, France 

¹⁷ Institut Paoli-Calmettes & Aix Marseille University, INSERM, IRD, SESSTIM, Marseille, France 

¹⁸ Department of Clinical Genetics, Odense University Hospital, Odense, Denmark 

¹⁹ Department of Clinical Research, University of Southern Denmark, Odense, Denmark 

²⁰ Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark

Poster 33

Paired DNA and RNA Sequencing from 450,000 Consecutive Individuals: Impact on Yield in Hereditary Breast, Ovarian, Pancreatic, and Prostate (HBOP) Cancer Genes 
 

Carolyn Horton, Magan Trottier, Lily Hoang, Jessica Grzybowski, Heather Zimmermann, Jesus Ramirez Castano, Sami Belhadj, Marcy Richardson, Rachid Karam    

Ambry Genetics 

Poster 34

RNF168-Dependent and -Independent Mechanisms of Homologous Recombination DNA Break Repair
 

Mohit Rajput, Mary Claire Kendall, Aarsh Patel, Rohan Rao, Prabagaran Esakky, John Krais 

Division of Oncology, Department of Medicine, Washington University School of Medicine in St Louis

Poster 35

DNA Repeat Transcription as a Means to Sensitize BRCA1-Deficient Breast and Ovarian Cancers to ATRi
 

Muzaffer Kassab¹, Rahul S. Mandal¹, Chandan Das¹, Nishita Shastri², Lewis A. Chodosh¹, Irfan A. Asangani¹, and Eric J. Brown<sup>1   

1</sup> Abramson Family Cancer Research Institute and Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104   

² BreakSight, Inc., 7540 Windsor Drive, Suite 210, Allentown, PA, 18106 

Poster 36

Deep Learning Variant Annotation Methods Increase Pathogenic Variant Detection in Women with High-Risk Breast Cancer and Nominate Candidate Noncoding Variants.
 

Mwangala Akamandisa¹, Bradley Wubbenhorst¹, Danielle Gutman¹, San Jewell¹, Farica Zhuang¹, Di Wu¹, Kurt D'Andrea¹, Shaurya Khanna¹, Heather Symecko^1,3, Rhonda Gillete^1,3, Payal Shah^1,3, Angela Bradbury^1,3, Dezheng Huo², Kara Maxwell^1,3, Yoseph Barash¹, Susan Domchek^1,3, Katherine Nathanson<sup>1,3 

1</sup> University of Pennsylvania

² University of Chicago

³ The Basser Center for BRCA

Poster 37

Investigating the Impact of BRCA1/2 mutation on Parity-Induced Protection Against Breast Cancer in Rat Models
 

Ashvathi Raghavakaimal¹, George K Belka¹, Nathan Mears¹, Lewis A Chodosh<sup>1 

1</sup> Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Poster 38

BRCA1 Haploinsufficiency Promotes Early Tumor Onset and Epigenetic Alterations in a Mouse Model of Hereditary Breast Cancer
 

Carman Man-Chung Li¹, Alyssa Cordes¹, Michael U J Oliphant¹, S. Aidan Quinn^2,3, Mayura Thomas¹, Laura M. Selfors¹, Francesca Silvestri¹, Nomeda Girnius¹, Gianmarco Rinaldi¹, Jason J. Zoeller¹, Hana Shapiro¹, Christina Tsiobikas¹, Kushali P. Gupta¹, Shailja Pathania^4,5, Aviv Regev^6,7, Cigall Kadoch^2,3, Senthil K. Muthuswamy^8,9, and Joan S. Brugge<sup>1,3

1</sup> Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
² Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA
³ Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
⁴ Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
⁵ Present address: Department of Biology, University of Massachusetts Boston, Boston, MA 02125 USA
⁶ Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
⁷ Present address: Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
⁸ Cancer Research Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
⁹ Present address: Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD 20850, USA

Poster 39

Exploring the Impact of BRCA1/2 Mutations on the Tumor Microenvironment in Triple-Negative Breast Cancer (TNBC) 
 

Dana Pueschl¹, Danielle Bragen¹, Victoria Fang^2,3, Jia-Ren Lin⁴, Derek Oldridge⁵, Anupma Nayak², Kate Bennett⁶, kConFab Investigators⁷, Antonis Antoniou⁸, Georgia Chenevix-Trench⁹, E. John Wherry^3,10,11, Susan M. Domchek^12,13, Katherine L. Nathanson<sup>1,12,13

1</sup> Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

² Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA

³ Institute for Immunology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA

⁴ Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA

⁵ Center for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, PA, USA

⁶ Gastroenterology Division, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA

⁷ Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Research Department, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia

⁸ Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK

⁹ Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

¹⁰ Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

¹¹ Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA

¹² Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA 

¹³ Basser Center for BRCA, University of Pennsylvania, Philadelphia, PA, USA